Expression of a transcript and abundance of the corresponding protein in ten tissue samples

Expression of a transcript and abundance of the corresponding protein in ten tissue samples

Running mRNA-sequencing and protein mass spectrometry on the same samples allows comparing the transcript expression and protein abundance of all genes. For the gene studied here, we see significant correlation between the mRNA and protein levels. Strong correlation enables using one data type as a proxy for the other in applications such as molecular diagnostics. Low correlation between the mRNA and protein levels may indicate the presence of strong post transcriptional or -translational regulation of the gene in question.